Dowanhowee, a Native American woman, evades the notorious Dutch Wilder Gang by escaping into the uncharted Black Wood Forest. Once inside, they quickly discover they must help each other for they have unknowingly awaken an ancient ravenous creature, known as The Wendigo.
For her first day of orientation, Dr. Tristian Mackenzie makes her way to the Silverdale Psychiatric Hospital for the criminally insane, where she learns of the strange series of cases from the similarly strange Dr. Moon.