The fifth-year residents return for the first day of a year that will make or break their careers: Meredith faces the consequences of tampering with Derek's clinical trial and is terminated at the hospital; April tries to step up to the plate as Chief Resident in the wake of a giant sinkhole in the middle of Seattle; and Cristina and Owen are still at odds over their drastically different feelings for their unborn child.
A dedicated, strait-laced FBI agent and a street-smart CIA agent are part of a new, clandestine taskforce charged with solving and preventing domestic terrorism in and around New York City.
