The Practice focused on the law firm of Robert Donnell and Associates (later becoming Donnell, Young, Dole, & Frutt, and ultimately Young, Frutt, & Berluti). Plots typically featured the firm's involvement in various high-profile criminal and civil cases that often mirrored current events at the time of the episodes' initial broadcast. Conflict between legal ethics and personal morality was a recurring theme.
A diverse group of tourists on an organized trip to Lisbon find themselves investigating a murder after one of them is killed on the first morning. Set out to find the killer among the group as they visit beautiful Lisbon sites.